Autophagy in health and disease
Autophagy is a conserved degradative pathway essential in a growing number of physiological processes and associated to the physiopathology of numerous diseases including cancer and neurodegeneration. Despite the medical relevance of autophagy, the mechanism and regulation of this pathway remain largely unclear. Those are studied in my laboratory using yeast Saccharomyces cerevisiae as a model organism, and biochemical, cell biological and electron microscopy methods in combination. My long-term objective is to understand the role of autophagy in specific medically relevant pathological situations. The first step in this direction has been to study how coronaviruses subvert the autophagy machinery to invade host cells. This type of research has now been extended to other viruses and represents an alternative approach to investigate the molecular mechanism of autophagy.