In the 1990s, the Human Genome Project was an international scientific research project aiming at determining the sequence making up the human DNA and to identify and map the human genome from physical and functional perspectives. The project was successfully completed in April 2003. This initiative had a profound effect in drug discovery, allowing a more rational design of new drugs, including in Cancer research. Since this achievement, the capacity to determine the genome increased dramatically to the point of becoming a routine method of analysis. The amount and the complexity of data generated during those studies are enormous and is becoming increasingly difficult to handle with the apparition of the newest genomic sequencers.
All BRIO research programs contain an element of genomics, making the analysis and management of those data a critical issue.
The bioinformatics research deals with the storage and analysis of genomics data and more specifically :
- The development of tools enabling the access, the use and the management of sequencing data.
- The development of new mathematical methods to understand and analyse large data sets.
Bioinformatics tools are especially important for the development of personalised medicine and the determination of patient response to targeted therapies, both themes being central in the BRIO research programs.
BRIO uses the excellent facilities available at Bordeaux University (at the Centre de BioInformatique de Bordeaux, CBiB) and the Laboratoire Bordelais de Recherche Informatique, LABRI), to consolidate and expand the bioinformatic research within its programs. In addition, BRIO recruited a bioinformatics specialist, Carlo Lucchesi, as a dedicated resource to support cancer bioinformatics projects.