In-Vivo models for cancer research

  • In-vivo pharmacology
French laws concerning animal care and GMO for the use in research and with the European ethical rules
Localization
Université de Bordeaux
DEMANDE D'UTILISATION

Contact

Description

Experimental approaches using rodents in oncology and development of mouse models for cancer research

We support the cancer research community in Bordeaux by facilitating and optimizing the development and use of in-vivo, preclinical models of the disease.
In this specific area we have developed specialised competences and skills and our staff is highly trained. We are able to produce rodent models, perform tumor grafts (xeonografts and syngeneic) and provide follow-up of tumor growth in different sanitary and security environments (A1, A2). Our housing facilities are in agreement with the French laws concerning animal care and GMO for the use in research and with European ethical rules.
We can provide cancer researchers in Bordeaux with wt/transgenic lines and highly trained staff capable of executing experimental tasks as a service (tumor cell injection, tumor growth follow-up, live-imaging, treatment, tumor resection etc…) to ensure the best quality and reproducibility.

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Activity

We provide cancer researchers in Bordeaux with:
  • wt and transgenic mice production
  • Cryopreservation of mouse lines
  • Tumor xenografts (tumor cell injection, tumor growth follow-up, live-imaging, treatment, tumor resection etc…)
  • Follow-up of tumor growth in different sanitary and security environments (A1, A2)

Infrastructure and equipment

Our department includes 4 different animal house facilities with highly competent staff with specific and complementary expertise: 2 A1 facilities, one A2 facility and conventional - Biospace live luminescence imager

Publication

  1. Vacher P, Vacher AM, Pineau R, Latour S, Soubeyran I, Pangault C, Tarte K, Soubeyran P, Ducret T, Bresson-Bepoldin L. Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas. J Immunol. 2015 Sep 1;195(5):2207-15.
  2. Verbeke S, Richard E, Monceau E, Schmidt X, Rousseau B, Velasco V, Bernard D, Bonnefoi H, MacGrogan G, Iggo RD. Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells. Breast Cancer Res. 2014 Dec 20;16(6):504.
  3. Chodoeva A, Bosc JJ, Lartigue L, Guillon J, Auzanneau C, Costet P, Zurdinov A, Jarry C, Robert J. Antitumor activity of semisynthetic derivatives of Aconitum alkaloids. Invest New Drugs. 2014 Feb;32(1):60-7.
  4. Auf G, Jabouille A, Delugin M, Guérit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor. BMC Cancer. 2013 Dec 13;13:597.
  5. Bianco S, Lanvin O, Tribollet V, Macari C, North S, Vanacker JM. Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferation. J BiolChem. 2009 Aug 28;284(35):23286-92.

Collaboration

  • Chien CC, Chen HH, Lai SF, Wu KC, Cai X, Hwu Y, Petibois C, Chu Y, Margaritondo G. Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature. J Nanobiotechnology. 2012 Mar 12;10:10.
  • Chien CC, Cheng CC, Chen HH, Hwu Y, Chu YS, Petibois C, Chen A, Ching YT, Margaritondo G. X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues. Anal Bioanal Chem. 2012 Sep;404(5):1287-96.
  • Chien CC, Chen HH, Lai SF, Hwu Y, Petibois C, Yang CS, Chu Y, Margaritondo G. X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells. Sci Rep. 2012;2:610. doi: 10.1038/srep00610. Epub 2012 Aug 29.  Institute of Physics, Academia Sinica, Nankang, Taipei 115, Taiwan, Toulouse, Paris, Rennes