Sarcomas

 

Sarcoma is a malignant tumour affecting connective tissues, muscular tissues or bones. Those tissues constitute two thirds of the human body and are involved in a number of key functions such as protection, nutrition, liaison, tissue regeneration, movement, immune response, growth or storage. Human sarcomas are rare: around 1% of all new cancer cases, and are found accross all ages. While recent molecular and genetic advances have helped to refine their classification, their diagnosis and therapeutic care still remain a challenge. Conventional chemotherapy as well as targeted therapies failed to provide a long term efficient response. IMS (Integrated medecine for sarcomas), which aims to take part of the recognised expertise of the scientific and medical community of Bordeaux, is a multidisciplinary program that allow experts in genetics, psychology, sociology, epidemiology to work together toward better treatment strategies for sarcomas.

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IMS is an ambitious programme dedicated to the enhancement of global outcome of patients with sarcomas through a multidimensional approach integrating:

  • Genomic driven clinical research and massive data integration to improve tumour biology knowledge and to assess impact of new therapies,
  • Pre-clinical investigations to identify new therapeutic targets,
  • Psychological and sociological research to assess impact of sarcoma diagnosis from a patient and society perspective,
  • Epidemiology research to improve environmental exposure assessment as part of a better understanding of the environmental etiology of sarcomas.

IMS coordinators are :

Each dimension of the program dimension are classified in tasks (divided itself in several research programs)  :

The first task « Integration of massive sequencing data to identify molecular networks of sensitivity and resistance to systemic therapies in sarcomas » is led by Dr Carlos Lucchesi, bioinformatician at Institut Bergonié.

In collaboration with H. and C. Fridman from the Laboratoire du microenvironnement immunitaire et des tumeurs, Inserm Paris, the task « Predictive and prognostic value of immunological profiling of soft-tissue sarcoma » is led by Dr Maud Toulmonde, oncologist at Institut Bergonié.

« Metabolic profiling of sensitivity and resistance to targeted therapies in sarcomas and other rare tumours » is led by Dr Rodrigue Rossignol, senior research scientist, team Maladies rares : génétique et métabolisme (MRGM).

« Radiomics Analysis for Characterisation of Prognosis and Treatment Response in Soft Tissue Sarcomas » is led by Dr Amandine Crombe, radiologist at Institut Bergonié.

In collaboration with the SIRIC SOCRATE, the task « make personalised medicine available for sarcoma patients and determination of the methods to communicate about these new practices to the patient » is led by Dr Sylviane darquy, research scientist in the Laboratoire d’éthique médicale et médecine légale, Inserm.

« Development and and assessment of faisability and efficacy of e-MBCR (web-Mindfulness Based Cancer Recovery) program (faisability and efficacy) » is led by Dr Marion Barrault, psychologist at Institut Bergonié and searcher in the Laboratoire de psychologie at University of Bordeaux.

« Emerging environmental factors and sarcomas » is led by Prof. Simone Mathoulin-Pélissier, professor of epidemiology and publich health, head of the team EPICENE, Inserm.

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