Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial.

Cancer medicine, May 2018

Italiano A, Touati N, Litière S, Collin F, Pourquier P, Gronchi A.

doi: 10.1002/cam4.1403

https://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002%2Fcam4.1403

Abstract

We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems.

© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.