Despite medical innovation, inequalities in Cancer treatment exist, for example people from the most disadvantaged socioeconomic background remain the most likely to suffer and die from Cancer. Economical, geographical, environmental, nutritional or individual differences can lead to disparities in access to health care, treatment and prognosis. At present, only a limited number of studies documented the reason for those disparities and proposed actions against them. Yet, Cancer patient survival rates improve regularly especially thanks to new diagnostic tools and improved treatments. More Cancer can be cured, others still remain difficult to cure, while others evolve slowly and are treated as a chronic disease.
BRIO wants to develop a translational axis in epidemiological research, covering clinical research to demographic research. The aim will be to concentrate on patient care outcome and the impact on the community through individual and collective factors (the individual or the patient, the tumour, the environment). BRIO will try to assess the optimal use of the available resources to improve prevention, diagnostic and treatment of Cancer.
BRIO main objectives are :
- Definition of relevant quality criteria on the outcome of patient care. Those criteria will be analysed based on patient characteristics and also patient care, treatment and outcome. The development of those criteria and their applications will allow :
- The identification of processes to limit the disparities in the access to care;
- The measurement of the impact of those processes.
- The Cancer patient monitoring will allow the assessment of post-diagnostic events (progression, relapse, reduced autonomy, death, second Cancer, toxicity…) : the aim being to identify clinical, biological and environmental factors influencing those events and to propose alternative treatment options to the patient presenting the higher risks.
All BRIO research programs already have or will integrate this axis in their research.
BRIO supports the creation of a research unit in Public Health and Epidemiology around those issues.
BRIO has access to a dedicated structure with :
- The Cancer population registry in Gironde (certified by the National Institute for Public Health Surveillance);
- Two Clinical Investigation Centres (CIC-EC07 et CIC-P 0005) and the data processing centre (CTD) for clinical trials (certified by INSERM);
- Rare tumour databases (sponsored by the INCA);
- A geriatric platform across multiple regions (certified by the French National League against Cancer).
Several research entities are involved through their clinicians, pathologists, caregivers, researchers, biologists, biostatisticians and epidemiologists :
- Universities Hospitals (CHU Bordeaux, Bergonié Institute)
- INSERM research Units (U897, axe Cancer, U657)
- SFR Public Health and Society
- Bordeaux University
- Regional Cancer Network