Sarcoma is a malignant tumour affecting connective tissues, muscular tissues or bones. Those tissues constitute two thirds of the human body and are involved in a number of key functions such as protection, nutrition, liaison, tissue regeneration, movement, immune response, growth or storage. Human sarcomas are rare: around 1% of all new cancer cases, and are found accross all ages.


BRIO research program is based on the competences and structures established within the Bergonié Institute around Prof. J.M. Coindre and Dr. B. Bui:

  • A complete and performing technical platform with an experienced team (the Bergonié Institute Sarcoma Unit), covering all aspects of sarcoma patient management (imaging, surgery, pathobiology, radiotherapy, and medical oncology)
  • A research unit dedicated to the biology of sarcomas with an experienced team of researchers within the INSERM unit VINCO U916
  • The management of databases collecting data on multidisciplinary teams aimed at the survey and evaluation of sarcoma patient’s care (treatment data for 12 000 patients and 5500 frozen tumours available for analysis)
  • A strong involvement in clinical research and trials (24 running clinical trial in 2013)

The main objectives of the sarcoma program are to:

  • Build a model to facilitate the data transfer between care and research by using standardized data in medical records;
  • Evaluate medical practices (diagnosis, treatment) by using quality criteria and promoting corrective actions through sarcoma French networks;
  • Improve knowledge in the field of sarcoma biology;
  • Develop and transfer to the daily practice our knowledge in molecular biology of sarcomas in order to improve diagnostic, prognostic and predictive tools as well as to identify new therapeutic targets;
  • Promote innovative clinical trials in order to evaluate these new targets;
  • Improve outcomes by enhancing quality in locoregional treatments.